The 'i' Scroll detail: Kundalini Rising
SOMAGENICS & SOMAGETICS 202
And we continue, those hardy souls looking for a way out of life's mess, to examine the remarkable properties of Sacred Syrian rue or SOMA. Heaps of interesting stuff in store for those who want to save a few bucks on their medical bills. And if you got here by way of the Superstitions Treasure hunt then you will probably end up finding gold and more. Gold mixed with other things is sometimes nicer. Best conductor known to man though is gold... and if your third-eye is activated when you get into the Superstitions you are going to be conducted towards the golden treasure. It is there for the taking, but there is RISK.
11 Antimicrobial Agents from Higher Plants. Antimicrobial Agents from Perganum harmala seeds.
Anti-microbial properties were also demonstrated in the paper: 'Antimicrobial Agents from Higher Plants. Antimicrobial Agents from Perganum harmala seeds', -Al-Shamma A, Drake S, Flynn D L, Mitscher LA, Park YH, Rao GS, Simpson A, Swayze JK, Veysoglu T, Wu ST. For more detail see http://www.ncbi.nlm.nih.gov/pubmed/7334386
Because Ananda included an aside here i will do so also:
Let's call it S & S 202:12-A just to be preposterous -
S & S 202: 12-A
The al-CHEM-ical tradition asserted that rue was a neutralizer of snake poison and this is confirmed by the anti-toxicological effects described in some of the learned sources quoted. Rue's beta-carbolines demonstate a neutralization effect against poison - a must in the Superstitions where, if you are not on good terms with them, rattlers can be a problem. Treasure hunters inevitably end up face to face with rattlesnakes - it goes with the territory. It was upheld for a long time, in the al-CHEM-ical traditions, that Christ was given Gal (snake poison), and this is also mentioned in the Nag Hammadi Gnostic Gospels, found in Egypt. It was also understood that the vinegar he received before 'giving up his Spirit' was the Vinegar of the Four Thieves, famous in al-CHEM-y, and named after the Blessed Christ - the central ingredient of this is Perganum harmala.
Rue was also the major treatment and protection against the plague. Anti-plague and anti-venom all in one. In Greek the word for Christ's body is 'soma' and the eucharist is partially based on 'eat my body'. In early Gnostic art there are many depictions of the Apostles casting demons from people after they have been given an elixir. It is not surprising that in order to vomit out the 'demons' (the illnesses they suffer) that increased dosages of Perganum harmala in natural form would be prescribed. [Ed: Ananda adds that rue is still used in this fashion in the Islamic tradition - i do not know that for sure.]
12 Synthesis and Pharmacological Evaluation of 1,2,3,4-tetrahydro-betacarboline derivatives.
A series of 1,2,3,4-tetrahydro-beta-carbolines has been synthesized and evaluated for cerebral protecting effects against lipid peroxidation and potassium cyanide intoxication in mice. Most of the compounds synthesized had potent effects against lipid peroxidation. Among them, 1-(3,5-dimethoxyphenol)-2-propyl-1,2,3,4-tetrahydro-beta-carboline (22) was found to have a combination of potent effects against both lipid peroxidation and potassium cyanide intoxication. Structure-activity relationships are discussed.
Kawashima Y; Horiguchi A; Taguchi M; Tuyuki Y; Karasawa Y; Araki H; Hatayama K: Chem Pharm Bull (Tokyo): 43:5:783-7 (1995)
13 Four Flavonoid Glycosides from Perganum harmala
The aerial parts of Perganum harmala yielded four new flavonoids and the glycoflavone 2''''-O-rhamnosyl-2''-O-glucosylcytisoside.
The Egyptian had to translate this for us from Arabic -
Sharaf M, el-Ansari MA, Matlin SA, Saleh NA, National Research Centre, Cairo, Egypt. PMID: 9014375, UI: 97166655
Harmaline and pinoline instigate all of the above, both flavinoid glycosides and the glycoflavone. If you have any elementary knowledge of psychopharmocology you may find this interesting.
Just about every drug you have been prescribed for a mental illness may NOT work. No don't throw them out yet, they still have to go and investigate this stuff further and you may need to stay leveled on your current dosage.
So - rue has the makings of the perfect anti-depressant, without the dangerous side effects of Prozac and other mood-inhibitors such as serotonin-based drugs. Hence, healthy pineal gland activity, by practise of Alpha-wave entrainment, at 7.83 Hz, instigated by superlearning techniques, Sylvia Mind Method, Mental Photography, Einstein-focusing Technique and its expanded daughter field image streaming, along with Meditation and Taoist martial arts such as Tai Chi and Chi Kung, and coherent emotion and breath patterns, aid in pineal gland pinoline turnover.
'Meditation' is simply an Alpha brain-wave entrainment technique which synchronizes the two brain hemispheres into 7.83 Hz, the frequency at which DNA replicates. Just by closing your eyes you stop melatonin leakage to the body and it thus saturates the neo-cortex, hence an increased production of melatonin and pinoline. Note carefully that flow is not stopped to the body, but it is increased to the two now-synched hemispheres.
This gives an extra impetus to Meditation, several times a day, as an essential health exercise. It's an energizer, taken with your daily coffee, and it makes you actually enjoy what you are doing during the day. Me - i am enjoying doing this - Plogging.
The extra pinoline and other beta-carboline levels that result, aid the body cells to replicate, and micro-organisms, parasites, fungoids, and bacteria (and other harmful creepy crawlies) to be neutralized.
Pinoline and melatonin give beneficial anti-oxidant properties to the body, and are the most useful anti-oxidants the body produces. So you are getting a rest break, a workout, an integration session, an energizer, body sculpture and a vitamin break. Most vitamins, like C, A and E, act as anti-oxidants.
Furthermore, it is an anti-depressant, increasing serotonin (5-HT) turnover, and recycling other essential neurotransmitters. It is the 100% clean green no contraindications and British Pharmaecopeia in the brain and body, recycling all of the essential neurotransmitter hormones.
But as the Mexican said: 'i don't need that stuff, i already enjoy making tortillas'.
14 Binding of Pinoline on the 5-hydroxy-tryptamine Transporter: Competitive Interaction with [3H] Citalopram
Pinoline (6-MeO-THBC) is a naturally occurring compound in the mammalian body which inhibits 5-hydroxytryptamine (5-HT) uptake and exerts antidepressant-like behavioural effects in rats (including the President of the ACNZ for Life Mr Rat).
'Stairway to Hell
LONDON -- Scientists who blasted drugged mice with loud dance music have received an official reprimand.
Seven mice died when they were forced to listen to The Prodigy after being given a strong form of amphetamine, and others suffered brain damage.
Four mice made to listen to a Bach piece of a similar tempo to The Prodigy song also died.
Britain's Home Office said it had taken 'infringement action' against the Cambridge University team.
But team leader Dr Jenny Morton said the study, part of a wider one looking at the affect of amphetamine on a brain area that degenerates in Huntingdon's disease, was fully justified and conducted responsibly.
The researchers said the sound caused the mice to suffer more drug-induced brain damage than normal. -- PA.
Proof that scientists are a little strange, inanga, 'Travel Notebooks' 2001 [Ed note: i guess it was neither Bach nor The Prodigy but the amphetamines that killed the poor mice; sounds hideously like cruelty to animals and that the good 'Dr' has never been to a 'rave'. i was listening to QOTSA's 'Songs for the Deaf' when i wrote this.]
This study investigates the effects of pinoline on [3H] citalopram binding to the 5-HT transporter on president Rat's brain. The experiments revealed that pinoline inhibits [3H] citalopram binding with IC50 1255 +/- 167 nM and Ki 572 +/- 76 nM [explanation later if you need it...]; Hill coefficient for inhibition was close to 1. In saturation experiments, pinoline co-incubated with [3H] citalopram, increased dose-dependently the Kd value but had no effect on the Bmax value of [3H] citalopram binding.
Micromolar concentrations of pinoline did not have influence on the dissociation rate of specifically bound [3H] citalopram.
Binding parameters of [3H] citalopram did not differ significantly in cerebral cortex and hippocampus of rats treated for 10 days with pinoline or vehicle. These results indicate that pinoline did not have any modulative influence on the activity on the activity of the 5-HT transporter and it interacts competitively with citalopram on the substrate recognition site of the 5-HT transporter.
Pahkla, R; Rago, L; Callaway JJ; Airaksinen, MM: A-4626. Pharmacol Toxicol: 80:3:122-6 (1997)
Pinoline and harmine as well as other beta-carbolines inhibit the mono-amino-oxidase (MAO) enzyme. In a process called oxidative deamination, MAO converts as much as 80 percent of the body's serotonin into a physiologically inactive metabolite. As serotonin binds to the enzyme's active sites MAO removes the amine function and renders the molecule harmless and ineffective.
A small oral dose of 22-52 milligrams, will temporarily prevent physiologically active amines, like sertonin, from binding to the active site of the MAO [mono-amino-ozidase] molecule and undergoing deamination. This continues for three to six hours, where the harmala alkaloids interfere with the function of MAO before their action is reversed and MAO actively restored.
Hence, inhibiting MAO softly means that there is a much larger turnover of serotonin which renders a major anti-depressant effect, as St. Johns Wort has shown on winter depression studies. Underlying this is another question. It is not just the depression caused by light (waking hours) but the depression caused by the lack of darkness (as studies conducted at Guantanamo Bay, Cuba, have probably already revealed) because pinoline production is produced in sufficient quantities only in conditions of darkness. Lack of darkness (eg sleep) = depression.
What the above and now following studies are showing is that lack of pinoline disturbs 'normal functioning in daily life'. Always trust the Mexican, the Clown and the Egyptian - the Superstitions is no place to be depressed. If you are looking for treasure you should be happy! But never trust a Fool!
[Ed note: more on St John's Wort later, banned by the FDA in the USA, and yet used to treat over 70% of the cases of manic depression in Germany. It grows freely in the garden.]
15 Major Pharmacological Effects of 6-MeO-THBC, a Drug Elevating the Tissue 5-Hydroxy-tryptamine Level
Major pharmacological effects of 6-MeO-THBC are described. It seemed to have a weak effect of its own on 5-HT receptors.
It is concluded that most of the effects, like the increase in rectal temperature after peripheral administration and decrease and then increase after introhypothalamic application as well as the antagonism of the group toxicity of amphetamine without effect on norepinephrine toxicity or barbituate sleeping time,can result from the increase of tissue 5-HT-concentration and/or inhibition of 5-HT-uptake. [report translation, not me - Ed]
Airaksinen, MM; Ho BT; An R; Taylor, D: A-4634. Arzneimittelforscung: 28:I:42-6 (1978)
S & S 202 15-A [Ananda again, but it is sound...]
Pinoline and harmine, as well as other beta-carbolines inhibit the mono-amino-oxidaze enzyme. In a process called oxidative deamination, MAO converts as much as 80% of the body's serotonin into a physiologically inactive metabolite [almost next to useless!]. As serotonin binds to the enzyme's active sites MAO removes the amine function and renders the molecule harmless and ineffective.
A small oral dose of 22-52 milligrams will temporarily prevent physiologically active amines, like serotonin, from binding to the active site of the MAO molecule and undergoing deamination. This continues for three to six hours, where the harmala alkaloids interfere with the function of MAO before their action is reversed and MAO activity restored.
This 'softer' inhibition of MAO means there is a much larger production of serotonin and this provides a major anti-depressant effect (as exhibited by Hypericum perforatum (St Johns Wort) in winter depression studies. The salient factor here is depression is not only caused by the light, but by the lack of darkness. Pinoline plays a great part in depression/no depression, and it is only produced in sufficient quantities in darkness (close your eyes and the process begins in earnest).
These studies herein indicate that a lack of pinoline disturbs our circadian rhythms and brings on depression. It will be one of the most important NEUROTRANSMITTERS of the future.
16 Possible Endocrine Role of the Pineal Gland for 6-MeO-THBC, a Putative Endogenous Neuromodulator of the 3H: Imipramine Recognition Site.
[Ed note: OK, OK - treasure hunters you don't have to remember all this. i am just stressing that 'you will rue the day you forget your rue'. Just make sure it is in your day pack. The Fool and the Clown.]
The association of the pineal gland with circadian rhythms, and the growing evidence for a disruption or phase alteration of the circadian rhythms in depression make it TEMPTING to speculate the at 6-MeO-THBC could play an important role in the pathophysiology of depression.
Langer, SZ; Lee, CR; Segonzac, A; Tateishi, T; Esnaud, H; Schoemaker, H; Winbald, B: A-4630. Eur J Pharmacol: 102:2:379-80 (1984)
S & S 202: 16-A
One centrally significant factor to pinoline is that it boosts the immune system by at least 2.6 fold, as animal studies have demonstrated. However, this was with a high dosage, some 800-900mg, depending on one's weight, and hence some 5-6 teaspoons of SOMA. Please read all cautions on HIGH DOSAGES - be aware the intense effects can result for four hours.
[Understand that this is a natural plant, and if you ingest it you cannot be sure of the exact measurement of dosages. Having said that i have never had ill effects - Ed]
17 6-MeO-THBC (Pinoline): Effects on Plasma Renin Activity and Aldosterone, TSH, LH and Beta-endorphin levels in the President for Life of the ACNZ Mr Rat (and other Rats)
Plasma renin activity and the plasma concentrations of aldosterone, TSH, LH and beta-endorphin were radioimmunologically determined in rats after ip administration of 15mg/kg of 6-MeO-THBC, pinoline), a compound found to occur normally in mammalian and avian pineal glands.
A 2.6-fold increase of plasma aldosterone concentration was found and it was preceded by an increase of plasma renin activity. An increase was also found in beta-endorphin/beta-lipotrophin concentration. The effects of 6-MeO-THBC on plasma beta-endorphin/beta-lipotrophin levels may be mediated by the dopaminergic or 5-HT neurones.
Airaksinen, MM; Sainio, EL; Leppaluoto, J; Kari, I: A-4628. Acta Endocrinal (Copenhagen): 107:4:525-30 (1984)
18 Pinoline, a Beta-carboline Derivative in the Serum and Cerebrospinal Fluid of Patients with Schizophrenia
Baseline levels of pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carbolines (6-MeO-THBC) in the serum and cerebrospinal fluid (CSF) were determined with GLC-mass spectrometry in 13 unmedicated schizophrenic patients and 18 non-psychiatric controls.
A detectable concentration of 6-MeO-THBC was always present, but no differences were found between the schizophrenic and control groups.
The serum and the CSF levels of 6-MeO-THBC were not significantly related to such variables as sex, age, subtype of schizophrenia, the quality and/or intensity of the psychopathological symptoms, or the duration of the illness. The role of the indoleamines in the aetiopathogenesis of schizophrenia is discussed.
This feed is interesting: http://www.ncbi.nlm.nih.gov/pubmed/6476781
Rimon, R; Airaksinen, MM; Kari, I; Gynther, J; Venalainen, E; Heikkila, L; Ryyppo, J; Pallo, J: A-4629. Ann Clin Res: 16:3:171-5 (1984)
19 Identification and Quantification of 1,2,3,4-THBC, 2-methyl-1,2,3,4-THBC and 6-MeO-1,2,3,4-THBC as In Vivo Constituents of the President of the ACNZ for Life Mr Rat's Brain and Adrenal Gland.
Our Mr Rat is seen best in his gold and pounamu jocks in 'Whitebait and the Rat Visit Easter Island' in one of the hog galleries.
The identification and quantification of three 1,2,3,4-tetrahydro-beta-carbolines as normal constituents of rat brain and adrenal gland, using combined gas chromatographic/mass spectrometric techniques, are reported.
Qualitative analyses of these tissues led to the identification of 1,2,3,4-tetrahydro-beta-carboline (THBC), 2-methyl-THBC (2-MTHBC) and 6-MeO-THBC, as determined by observed peak retention times, mass fragments, and ion mass ratios.
Quantitative analyses, using deuterated internal standards, gave the following results: THBC (ng/g wet wt) in brain = 7.5 +/- 4.86, adrenal = 500.3 +/- 163.
6-MeO-THBC (ng/g wet wt) in brain = 35.6 +/- 16.6, adrenal = 113.7 +/- 300. [i have to verify these results - Ed]
Mechanisms for the formation of these beta-carbolines as well as their possible function in vivo are discussed.
Barker, SA; Harrison, RE; Monti, JA; Brown, GB; Christian, ST: A-4632. Biochem Pharmacol: 30:1:9-17 (1981)
Sorry about the length of this url, but it points to similar Japanese research:
20 The Cure for myriad other diseases - more on SEROTONIN and MELATONIN later.